The aim of this study was to evaluate the effect of gonadotrophin-releasing hormone (GnRH) antagonists on the hypothalamic-pituitary-gonadal (HPG) axis and to investigate the potential effect of clomiphene citrate on this axis. The present study was a prospective, controlled, randomized, single-center trial conducted in a tertiary center in the Philippines between January and December 2014.
We hypothesized that, in addition to being a selective hypothalamic-pituitary-gonadal (HPG) axis agonist, gonadotrophin-releasing hormone (GnRH) antagonists could also induce HPG axis in the hypothalamus. A total of 431 female patients with a body mass index (BMI) between 30.7 and 40.9 kg/m2 (mean 35.9 ± 7.6 kg/m2), with a mean age of 33.5 ± 8.3 years were recruited to the study. All patients were evaluated before starting treatment and after 3 months and then on the following 3 months. Patients with an BMI of 30.2 or higher were eligible for the study. Patients with a BMI of over 40 kg/m2 were excluded as this group did not have sufficient evidence of HPG axis in patients with hypogonadism.
The patients were followed up every year for a period of 1 to 3 months (median 6 months).
Patients in the study group were treated with clomiphene citrate (50 mg) at a dose of 1 mg/day for 1 week. For the first month of the study, the patients were administered clomiphene citrate (25 mg/day, 50 mg/day and 100 mg/day). The first month of the study was the first month of treatment, and the treatment was repeated every 3 months. For the second month, the patients were administered the following treatments: clomiphene citrate (25 mg/day, 50 mg/day, and 100 mg/day), which resulted in a reduction of the mean of the first three measurements. The last treatment was a second treatment (clomiphene citrate 25 mg/day, 50 mg/day, and 100 mg/day), which resulted in a reduction of the mean of the three measurements.
For the third month of the study, the patients were administered clomiphene citrate (25 mg/day, 50 mg/day and 100 mg/day), which resulted in a reduction of the mean of the first three measurements. The patients were instructed to keep on clomiphene citrate (50 mg/day, 50 mg/day and 100 mg/day) for the remainder of the study period, and then to take the study medication for the remainder of the study period.
All patients were instructed to follow up the follow-up visits every year for 1 year (1 year after their last treatment with clomiphene citrate). The patients were followed for a period of 7 years (4 years after their last treatment with clomiphene citrate).
The patients were instructed to continue the study treatment after the end of the treatment period and continue taking clomiphene citrate for the rest of the study period (6 months after the end of treatment).
The following patients were also instructed to take the study medication for the remainder of the study period:
The study medication consisted of a placebo, with clomiphene citrate (50 mg) taken as a placebo (the dose was 25 mg/day). The patients were instructed to continue the study treatment after the end of the study period. The study medication was continued after the end of the study period.
In the present study, we investigated the effect of treatment with gonadotrophin-releasing hormone antagonists on the hypothalamic-pituitary-gonadal (HPG axis) axis in the patients with a BMI between 30.2 and 40.9 kg/m2. In this study, a total of 431 female patients with a body mass index (BMI) between 30.7 and 40.9 kg/m2, with a mean age of 33.5 ± 7.
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Navigating the journey to conception can be challenging, but Clomid 50mg tablets are here to offer a helping hand. Designed with the aim to treat infertility in women, these powerful tablets work by stimulating ovulation, thereby increasing the chances of pregnancy. Each pack contains 10 tablets of 50mg, the recommended dosage to initiate the ovulation process effectively and safely.- How Does it Work? Clomid (Clomiphene Citrate) is a trusted medication in the reproductive field, known for its ability to encourage the release of hormones necessary for ovulation. This medication is typically prescribed for women who do not ovulate regularly. By simulating a natural increase in hormone production, Clomid helps to ensure that the ovaries release one or more eggs during the cycle.- When to Take Clomid? It's essential to follow your doctor's instructions when taking Clomid. Typically, the course starts early in the menstrual cycle and continues for five days. The exact timing can vary depending on individual health conditions and the specific advice of your healthcare provider.- Who Can Benefit? Clomid is particularly effective for women diagnosed with Polycystic Ovary Syndrome (PCOS) or other ovulatory disorders. It’s a beacon of hope for those who struggle with irregular ovulation, helping to restore normal cycles and increase the likelihood of conception. Remember, while Clomid is a potent ally in the quest for pregnancy, usage should be under strict medical supervision. Discuss with your healthcare professional to understand if Clomid is right for you and to tailor a treatment plan best suited to your personal health profile. With proper guidance, Clomid 50mg tablets can be a significant step toward making your dream of parenthood a reality.
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Clomid® has been approved for use by the FDA and is considered a safe medication when used as prescribed. Minor Clomid® side effects may include:
In less than 1% of cases, patients develop a condition known as ovarian hyperstimulation syndrome (OHSS). This is a serious and potentially life threatening condition. You should see a healthcare provider right away if you notice any of the following symptoms:
Clomid® use also increases the chance of multiple pregnancies (twins or triplets). The FDA has also reported potential conditions associated with clomiphene citrate use, including certain types of cancer and congenital abnormalities.
This isn’t a complete list of potential side effects. Speak with your healthcare provider directly about any symptoms you’re experiencing.
SIDE EFFECTS HEALTHCARE YOUR DOCTOR MAYcks This isn’t a complete list of potential side effects. Some side effects can be rare but serious and may affect the entire patient’s medication treatment course.Key Takeaways: Clomid® is a safe and effective medication for women who have ovulatory dysfunction, a condition in which the ovaries do not produce enough follicles to produce a mature egg.
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